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1

Applications of Physiologically Based Pharmacokinetic (PBPK) Modeling and Simulation During Regulatory Review

Zhao, P, Zhang, L, Grillo, J A, Liu, Q, Bullock, J M, Moon, Y J, Song, P, Brar, S S, Madabushi, R, Wu, T C

Journal:

Clinical Pharmacology & Therapeutics

Year:

2010

Language:

english

File:

PDF, 344 KB

english, 2010

2

Hyperforin in St. John’s wort drug interactions

Rajanikanth Madabushi, Bruno Frank, Bernd Drewelow, Hartmut Derendorf, Veronika Butterweck

Journal:

European Journal of Clinical Pharmacology

Year:

2006

Language:

english

File:

PDF, 143 KB

english, 2006

3

Impact of Pharmacometric Reviews on New Drug Approval and Labeling Decisions—a Survey of 31 New Drug Applications Submitted Between 2005 and 2006

Bhattaram, V A, Bonapace, C, Chilukuri, D M, Duan, J Z, Garnett, C, Gobburu, J V S, Jang, S H, Kenna, L, Lesko, L J, Madabushi, R

Journal:

Clinical Pharmacology & Therapeutics

Year:

2007

Language:

english

File:

PDF, 180 KB

english, 2007

4

Clinical Pharmacology Basis of Deriving Dosing Recommendations for Dabigatran in Patients With Severe Renal Impairment

Hariharan, S., Madabushi, R.

Journal:

Journal of Clinical Pharmacology

Year:

2012

Language:

english

File:

PDF, 236 KB

english, 2012

5

Chronic Pain in a patient with Ehlers-Danlos Syndrome (hypermobility type): The role of Myofascial Trigger Point injections

Tewari, Saipriya, Madabushi, Rajashree, Agarwal, Anil, Gautam, Sujeet K., Khuba, Sandeep

Journal:

Journal of Bodywork and Movement Therapies

Year:

2016

Language:

english

File:

PDF, 578 KB

english, 2016

6

A Holistic and Integrative Approach for Advancing Model‐Informed Drug Development

Madabushi, Rajanikanth, Wang, Yaning, Zineh, Issam

Journal:

CPT: Pharmacometrics & Systems Pharmacology

Year:

2019

Language:

english

File:

PDF, 176 KB

english, 2019

7

4660013 Compact whole body resistive magnetic resonance imaging magnet

Evangelos T Laskaris, Madabushi V Chari

Journal:

Magnetic Resonance Imaging

Year:

1987

Language:

english

File:

PDF, 107 KB

english, 1987

8

5307039 Frustoconical magnet for magnetic resonance imaging

Madabushi V Chari, Evangelos T Laskaris, Michele D Ogle

Journal:

Magnetic Resonance Imaging

Year:

1995

Language:

english

File:

PDF, 106 KB

english, 1995

9

5436607 Open (non-enclosed) magnets for magnetic resonance imaging

V Chari Madabushi, T Laskaris Evangelos, Gary Bedrosian, D Ogle Michele

Journal:

Magnetic Resonance Imaging

Year:

1995

Language:

english

File:

PDF, 99 KB

english, 1995

10

Protection by vitamin E, selenium, trolox, ascorbic acid palmitate, acetylcysteine, coenzyme Q, β-carotene, and (+)-catechin against oxidative damage to rat liver and heart tissue slices measured by oxidized heme proteins

Cathérine L.C. De Mulder, Haripriya T. Madabushi, Al L. Tappel

Journal:

The Journal of Nutritional Biochemistry

Year:

1995

Language:

english

File:

PDF, 718 KB

english, 1995

11

Pulsed discharge emission detector: an element-selective detector for gas chromatography

W.E Wentworth, Kefu Sun, De Zhang, Janardhan Madabushi, Stanley D Stearns

Journal:

Journal of Chromatography A

Year:

2000

Language:

english

File:

PDF, 1.13 MB

english, 2000

12

Insights into the role of Val45 and Gln182 ofEscherichia coliMutY in DNA substrate binding and specificity

Po-Wen Chang, Amrita Madabushi, A-Lien Lu

Journal:

BMC Biochemistry

Year:

2009

Language:

english

File:

PDF, 1.23 MB

english, 2009

13

Pharmacokinetics of cefpodoxime in plasma and subcutaneous fluid following oral administration of cefpodoxime proxetil in male beagle dogs

V. KUMAR, R. MADABUSHI, M. B. B. LUCCHESI, H. DERENDORF

Journal:

Journal of Veterinary Pharmacology and Therapeutics

Year:

2011

Language:

english

File:

PDF, 263 KB

english, 2011

14

Vitamin E protects chick tissues againstex vivooxidation of heme protein

Haripriya T. Madabushi, Cathérine L. C. De Mulder, Al L. Tappel

Journal:

Year:

1996

Language:

english

File:

PDF, 321 KB

english, 1996

15

Misclassification and discordance of measured blood pressure from patient’s true blood pressure in current clinical practice: a clinical trial simulation case study

Yuyan Jin, Robert Bies, Marc R. Gastonguay, Norman Stockbridge, Jogarao Gobburu, Rajanikanth Madabushi

Journal:

Journal of Pharmacokinetics and Pharmacodynamics

Year:

2012

Language:

english

File:

PDF, 501 KB

english, 2012

16

An Angiotensin II type 1 receptor activation switch patch revealed through Evolutionary Trace analysis

Marie Mi Bonde, Rong Yao, Jian-Nong Ma, Srinivasan Madabushi, Stig Haunsø, Ethan S. Burstein, Jennifer L. Whistler, Søren P. Sheikh, Olivier Lichtarge, Jakob Lerche Hansen

Journal:

Biochemical Pharmacology

Year:

2010

Language:

english

File:

PDF, 426 KB

english, 2010

17

Interaction between human mismatch repair recognition proteins and checkpoint sensor Rad9-Rad1-Hus1

Haibo Bai, Amrita Madabushi, Xin Guan, A-Lien Lu

Journal:

Year:

2010

Language:

english

File:

PDF, 1.18 MB

english, 2010

18

Tea and Coffee Brews are not Dietary Sources of Vitamin K-1 (phylloquinone)

SARAH L. BOOTH, HARIPRIYA T. MADABUSHI, KENNETH W. DAVIDSON, JAMES A. SADOWSKI

Journal:

Journal of the American Dietetic Association

Year:

1995

File:

PDF, 223 KB

1995

19

Excited Species from a Pulsed Discharge in Helium at One Atmosphere Pressure

Wentworth, Wayne E., Qin, Yang, Wiedeman, Sophie, Stearns, Stanley D., Madabushi, Janardhan

Journal:

Applied Spectroscopy

Year:

1995

Language:

english

File:

PDF, 1.32 MB

english, 1995

20

Structural clusters of evolutionary trace residues are statistically significant and common in proteins

Srinivasan Madabushi, Hui Yao, Mike Marsh, David M Kristensen, Anne Philippi, Mathew E Sowa, Olivier Lichtarge

Journal:

Journal of Molecular Biology

Year:

2002

Language:

english

File:

PDF, 497 KB

english, 2002

21

A Structural Hinge in Eukaryotic MutY Homologues Mediates Catalytic Activity and Rad9–Rad1–Hus1 Checkpoint Complex Interactions

Paz J. Luncsford, Dau-Yin Chang, Guoli Shi, Jade Bernstein, Amrita Madabushi, Dimeka N. Patterson, A-Lien Lu, Eric A. Toth

Journal:

Journal of Molecular Biology

Year:

2010

Language:

english

File:

PDF, 1.36 MB

english, 2010

22

Exophytic choroid plexus papilloma of the fourth ventricle presenting with cerebrospinal fluid rhinorrhea: a case report

Nigel Peter Symss, Anantharaju N. Prasad, Madabushi C. Vasudevan, Ravi Ramamurthi

Journal:

Surgical Neurology

Year:

2009

Language:

english

File:

PDF, 337 KB

english, 2009

23

Active-Site Specificity of Digestive Aspartic Peptidases from the Four Species of Plasmodium that Infect Humans Using Chromogenic Combinatorial Peptide Libraries †

Beyer, Bret B., Johnson, Jodie V., Chung, Alfred Y., Li, Tang, Madabushi, Amrita, Agbandje-McKenna, Mavis, McKenna, Robert, Dame, John B., Dunn, Ben M.

Journal:

Year:

2005

Language:

english

File:

PDF, 272 KB

english, 2005

24

Vitamin D Deficiency-Induced Muscle Wasting Occurs through the Ubiquitin Proteasome Pathway and Is Partially Corrected by Calcium in Male Rats

Bhat, Mehrajuddin, Kalam, Ramesh, Qadri, Syed SYH, Madabushi, Seshacharyulu, Ismail, Ayesha

Journal:

Year:

2013

Language:

english

File:

PDF, 476 KB

english, 2013

25

Use of ultrasound-guided cryotherapy for the management of chronic pain states

Connelly, Neil Roy, Malik, Ashish, Madabushi, Lakshmi, Gibson, Charles

Journal:

Journal of Clinical Anesthesia

Year:

2013

Language:

english

File:

PDF, 285 KB

english, 2013

26

Effectiveness of clopidogrel dose escalation to normalize active metabolite exposure and antiplatelet effects in CYP2C19 poor metabolizers

Horenstein, Richard B., Madabushi, Rajnikanth, Zineh, Issam, Yerges-Armstrong, Laura M., Peer, Cody J., Schuck, Robert N., Figg, William Douglas, Shuldiner, Alan R., Pacanowski, Michael A.

Journal:

Journal of Clinical Pharmacology

Year:

2014

Language:

english

File:

PDF, 446 KB

english, 2014

27

Concentration-QT Relationships Play a Key Role in the Evaluation of Proarrhythmic Risk During Regulatory Review

Garnett, Christin E., Beasley, Nhi, Bhattaram, V. Atul, Jadhav, Pravi R., Madabushi, Rajanikanth, Stockbridge, Norman, Tornøe, Christoffe W., Wang, Yaning, Zhu, Hao, Gobburu, Jogara V.

Journal:

Journal of Clinical Pharmacology

Year:

2008

Language:

english

File:

PDF, 100 KB

english, 2008

28

[IEEE HCC 2001. IEEE Symposium on Human-Centric Computing Languages and Environments - Stresa, Italy (5-7 Sept. 2001)] Proceedings IEEE Symposia on Human-Centric Computing Languages and Environments (Cat. No.01TH8587) - Visualizing graphical and textual formalisms

Castello, R., Mili, R., Madabushi, H.

Year:

2001

Language:

english

File:

PDF, 141 KB

english, 2001

29

Essential Pharmacokinetic Information for Drug Dosage Decisions: A Concise Visual Presentation in the Drug Label

Menon-Andersen, D, Yu, B, Madabushi, R, Bhattaram, V, Hao, W, Uppoor, R S, Mehta, M, Lesko, L, Temple, R, Stockbridge, N, Laughren, T, Gobburu, J V

Journal:

Clinical Pharmacology & Therapeutics

Year:

2011

Language:

english

File:

PDF, 128 KB

english, 2011

30

Leveraging Prior Quantitative Knowledge to Guide Drug Development Decisions and Regulatory Science Recommendations: Impact of FDA Pharmacometrics During 2004-2006

Wang, Yaning, Bhattaram, A. Venkatesh, Jadhav, Pravin R., Lesko, Lawrence J., Madabushi, Rajanikanth, Powell, J. Robert, Qiu, Wei, Sun, He, Yim, Dong S., Zheng, Jenny J., Gobburu, Jogarao V. S.

Journal:

Journal of Clinical Pharmacology

Year:

2008

Language:

english

File:

PDF, 293 KB

english, 2008

31

Pharmacokinetic and Pharmacodynamic Basis for Effective Argatroban Dosing in Pediatrics

Madabushi, Rajanikanth, Cox, Donna S., Hossain, Mohammad, Boyle, Duane A., Patel, Bela R., Young, Guy, Choi, Young-Moon, Gobburu, Jogarao V. S.

Journal:

Journal of Clinical Pharmacology

Year:

2011

Language:

english

File:

PDF, 605 KB

english, 2011

32

Clopidogrel, CYP2C19 and proton pump inhibitors: What we know and what it means

Hariharan, Sudharshan, Southworth, Mary Ross, Madabushi, Rajanikanth

Journal:

Journal of Clinical Pharmacology

Year:

2014

Language:

english

File:

PDF, 130 KB

english, 2014

33

Moxifloxacin distribution in the interstitial space of infected decubitus ulcer tissue of patients with spinal cord injury measured by in vivo microdialysis

Burkhardt, Olaf, Derendorf, Hartmut, Jäger, Doris, Kumar, Vipul, Madabushi, Rajanikanth, Röhl, Klaus, Barth, Jürgen

Journal:

Scandinavian Journal of Infectious Diseases

Year:

2006

Language:

english

File:

PDF, 98 KB

english, 2006

34

Dosing Rationale for Liraglutide in Type 2 Diabetes Mellitus: A Pharmacometric Assessment

Ingwersen, Steen H., Khurana, Manoj, Madabushi, Rajanikanth, Watson, Estelle, Jonker, Daniël M., Thi, Tu Duyen Le, Jacobsen, Lisbeth V., Tornøe, Christoffer W.

Journal:

Journal of Clinical Pharmacology

Year:

2012

Language:

english

File:

PDF, 648 KB

english, 2012

35

Predicted impact of various clinical practice strategies on cardiovascular risk for the treatment of hypertension: a clinical trial simulation study

Jin, Yuyan, Bies, Robert, Gastonguay, Marc R., Wang, Yaning, Stockbridge, Norman, Gobburu, Jogarao, Madabushi, Rajanikanth

Journal:

Journal of Pharmacokinetics and Pharmacodynamics

Year:

2014

Language:

english

File:

PDF, 1.38 MB

english, 2014

36

Development and Validation of an HPLC Method for Oxytocin in Ringer's Lactate and its Application in Stability Analysis

Kumar, Vipul, Madabushi, Rajanikanth, Derendorf, Hartmut, Boothby, Lisa A., Breland, Burnis D., Hatton, Randy C., Doering, Paul L.

Journal:

Journal of Liquid Chromatography & Related Technologies

Year:

2006

Language:

english

File:

PDF, 153 KB

english, 2006

37

Essential Helix Interactions in the Anion Transporter Domain of Prestin Revealed by Evolutionary Trace Analysis

Rajagopalan, L., Patel, N., Madabushi, S., Goddard, J. A., Anjan, V., Lin, F., Shope, C., Farrell, B., Lichtarge, O., Davidson, A. L., Brownell, W. E., Pereira, F. A.

Journal:

Journal of Neuroscience

Year:

2006

Language:

english

File:

PDF, 330 KB

english, 2006

38

Evolutionary Trace of G Protein-coupled Receptors Reveals Clusters of Residues That Determine Global and Class-specific Functions

Madabushi, S., Gross, A. K., Philippi, A., Meng, E. C., Wensel, T. G., Lichtarge, O.

Journal:

Journal of Biological Chemistry

Year:

2004

Language:

english

File:

PDF, 861 KB

english, 2004

39

beta-Arrestin-dependent, G Protein-independent ERK1/2 Activation by the beta2 Adrenergic Receptor

Shenoy, S. K., Drake, M. T., Nelson, C. D., Houtz, D. A., Xiao, K., Madabushi, S., Reiter, E., Premont, R. T., Lichtarge, O., Lefkowitz, R. J.

Journal:

Journal of Biological Chemistry

Year:

2006

Language:

english

File:

PDF, 1.38 MB

english, 2006

40

Ultrasound guided interscalene block is a safe technique in neck breathers

Pujari, S. Vinayak, Madabushi, K. Rajashree, Bevinaguddaiah, Yatish, Iyer, S. Sadasivan

Journal:

Egyptian Journal of Anaesthesia

Year:

2014

Language:

english

File:

PDF, 710 KB

english, 2014

41

Surface Modification and Repair for Aircraft Life Enhancement and Structural Restoration

Liu, Qian Chu, Baburamani, Pud, Zhuang, Wyman, Gerrard, Darrem, Hinton, Bruce, Janardhana, Madabushi, Sharp, Khan

Journal:

Materials Science Forum

Year:

2010

Language:

english

File:

PDF, 1.24 MB

english, 2010

42

Conserved Motifs in Somatostatin, D2-dopamine, and 2B-Adrenergic Receptors for Inhibiting the Na-H Exchanger, NHE1

Lin, C.-Y., Varma, M. G., Joubel, A., Madabushi, S., Lichtarge, O., Barber, D. L.

Journal:

Journal of Biological Chemistry

Year:

2003

Language:

english

File:

PDF, 918 KB

english, 2003

43

Sorafenib for the Treatment of Unresectable Hepatocellular Carcinoma

Kane, R. C., Farrell, A. T., Madabushi, R., Booth, B., Chattopadhyay, S., Sridhara, R., Justice, R., Pazdur, R.

Journal:

Year:

2009

Language:

english

File:

PDF, 189 KB

english, 2009

44

Histone deacetylase SIRT1 modulates and deacetylates DNA base excision repair enzyme thymine DNA glycosylase

Madabushi, Amrita, Hwang, Bor‑Jang, Jin, Jin, Lu, A‑Lien

Journal:

Biochemical Journal

Year:

2013

Language:

english

File:

PDF, 1.05 MB

english, 2013

45

Pharmacokinetic Assessment in Patients Receiving Continuous RRT: Perspectives from the Kidney Health Initiative

Nolin, T. D., Aronoff, G. R., Fissell, W. H., Jain, L., Madabushi, R., Reynolds, K., Zhang, L., Huang, S. M., Mehrotra, R., Flessner, M. F., Leypoldt, J. K., Witcher, J. W., Zineh, I., Archdeacon, P.,

Journal:

Clinical Journal of the American Society of Nephrology

Year:

2015

Language:

english

File:

PDF, 490 KB

english, 2015

46

Postoperative Central Nervous System Infection (PCNSI) After Neurosurgery in a Modernized, Resource-Limited Tertiary Neurosurgical Center in South Asia

Chidambaram, Swathi, Nair, M. Nathan, Krishnan, Shyam Sundar, Cai, Ling, Gu, Weiling, Vasudevan, Madabushi Chakravarthy

Journal:

World Neurosurgery

Year:

2015

Language:

english

File:

PDF, 349 KB

english, 2015

47

Association of the Rad9–Rad1–Hus1 checkpoint clamp with MYH DNA glycosylase and DNA

Hwang, Bor-Jang, Jin, Jin, Gunther, Randall, Madabushi, Amrita, Shi, Guoli, Wilson, Gerald M., Lu, A.-Lien

Journal:

Year:

2015

Language:

english

File:

PDF, 2.16 MB

english, 2015

48

The human checkpoint sensor Rad9 Rad1 Hus1 interacts with and stimulates DNA repair enzyme TDG glycosylase

Guan, X., Madabushi, A., Chang, D.-Y., Fitzgerald, M. E., Shi, G., Drohat, A. C., Lu, A-L.

Journal:

Nucleic Acids Research

Year:

2007

Language:

english

File:

PDF, 576 KB

english, 2007

49

Personalized Cardiovascular Medicine Today: Figure.

Blaus, Alison, Madabushi, Rajanikanth, Pacanowski, Michael, Rose, Martin, Schuck, Robert N., Stockbridge, Norman, Temple, Robert, Unger, Ellis F.

Journal:

Year:

2015

Language:

english

File:

PDF, 690 KB

english, 2015

50

SIRT6 protein deacetylase interacts with MYH DNA glycosylase, APE1 endonuclease, and Rad9–Rad1–Hus1 checkpoint clamp

Hwang, Bor-Jang, Jin, Jin, Gao, Ying, Shi, Guoli, Madabushi, Amrita, Yan, Austin, Guan, Xin, Zalzman, Michal, Nakajima, Satoshi, Lan, Li, Lu, A-Lien

Journal:

BMC Molecular Biology

Year:

2015

Language:

english

File:

PDF, 1.95 MB

english, 2015

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